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Molecular response to multiple trace element contamination of the European sardineuse asterix (*) to get italics
Anaïs Beauvieux, Jean-Marc Fromentin, Claire Saraux, Diego Romero, Nathan Couffin, Adrien Brown, Luisa Metral, Fabrice Bertile, Quentin SchullPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"
2024
<p>In marine ecosystems, the presence of trace elements resulting from anthropogenic activities has raised concerns regarding their potential effects on marine organisms. This study delves into the intricate relationship between trace element contamination and the physiological responses of a key marine species in the Mediterranean Sea: the European sardine. Since 2008, this species has been experiencing a significant crisis in the region, prompting numerous studies to investigate the potential factors behind the dramatic decline in sardines size, age, and body condition. However, thorough information on chemical contamination by trace elements and its physiological impact on this species was lacking. We found evidence for the accumulation of multiple elements in sardines, with a light East-West contamination gradient within the Gulf of Lions. While macro-physiological parameters (i.e. body condition) were not affected by contamination, pathways involved in cellular organization and response to stress were clearly upregulated, particularly in the liver, but also in muscle. In addition, a global upregulation in processes linked to the immune system, lipid homeostasis and oxidative stress was recorded in the liver. The associated energetic cost may add a substantial burden to sardines that already face multi-factorial constraints. This study also allows to pinpoint biomarkers of exposure and effects that may be important for monitoring Mediterranean sardine health. The results of this study and particularly the complex changes in protein expression demonstrate the need for future studies to test the concomitant effects of multiple stressors acting simultaneously, including large scale contamination.</p>
https://doi.org/10.5281/zenodo.10683281You should fill this box only if you chose 'All or part of the results presented in this preprint are based on data'. URL must start with http:// or https://
https://doi.org/10.5281/zenodo.10683281You should fill this box only if you chose 'Scripts were used to obtain or analyze the results'. URL must start with http:// or https://
You should fill this box only if you chose 'Codes have been used in this study'. URL must start with http:// or https://
Cocktail effect, Ecotoxicology, Gulf of Lions, Sardina pilchardus, Shotgun proteomic
NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).
Biomarkers, Environmental pollution, Marine ecotoxicology
Emma L. Thompson [emma.thompson@mq.edu.au], Alexandre Campos [acampos@ciimar.up.pt], J.M. Guerra-García [jmguerra@us.es], Olivier Geffard [olivier.geffard@irstea.fr], Céline Vellinger [celine.vellinger@gmail.com], Jean Armengaud [jean.armengaud@cea.fr], Elodie BORCIER [elodie.borcier@univ-brest.fr ] No need for them to be recommenders of PCI Ecotox Env Chem. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct
e.g. John Doe [john@doe.com]
2024-02-22 16:24:52
Davide Anselmo Luigi Vignati